Endocrine Abstracts

Introduction: Patients with hypothyroidism are routinely advised to take levothyroxine without food or beverages but the pharmacokinetic effect of many common foods are unknown. We describe a patient with an unusually high levothyroxine requirement who only achieved adequate replacement by taking grapes along with levothyroxine. Through a cycle of challenge, withdrawal, and-re-challenge, we were able to demonstrate that levothyroxine availability was enhanced by grapes in this...